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From the *Department of Anesthesiology, Aretaieio Hospital, Medical School; and
Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Athens, Athens, Greece.
Address correspondence to A. Fassoulaki, MD, PhD, DEAA, 57-59 Raftopoulou St., 11744 Athens, Greece. Address e-mail to afassou1{at}otenet.gr or fassoula{at}aretaieio.uoa.gr.
BACKGROUND: Acupressure on the "extra 1" point decreases bispectral index (BIS) values and stress.
METHODS: We investigated the BIS, melatonin, ß-endorphin, and verbal stress score values before, after 10 min of acupressure application on the extra 1 point, on a sham point, after no acupressure, and 1 h after completion of each intervention in 12 volunteers.
RESULTS: The BIS and verbal stress score values were decreased after acupressure on the extra 1 point (P = 0.0001 and P = 0.008, respectively), but melatonin and ß-endorphin did not change.
CONCLUSION: Acupressure on the extra 1 point has no effect on melatonin and ß-endorphin levels.
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