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ANESTHETIC PHARMACOLOGY

Landiolol, an Ultra–Short-Acting ß1-Adrenoceptor Antagonist, Does Not Alter the Minimum Alveolar Anesthetic Concentration of Isoflurane in a Swine Model

From the Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan.

Address correspondence and reprint requests to Tadayoshi Kurita, MD, Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. Address e-mail to tadkur{at}hama-med.ac.jp.

BACKGROUND: We previously reported that landiolol, an ultra–short-acting ß1-adrenoceptor antagonist, does not alter the electroencephalographic effect of isoflurane. Here, we investigated the influence of landiolol on the minimum alveolar anesthetic concentration (MAC) of isoflurane required to prevent movement in response to a noxious stimulus in 50% of subjects.

METHODS: Ten swine (29.0 ± 3.4 kg) were anesthetized by inhalation of isoflurane. MAC was determined using the dewclaw clamp technique, in which movement in response to clamping is recorded. After determination of MAC in the baseline period, an infusion of landiolol (0.125 mg · kg^–1 · min^–1 for 1 min, then 0.04 mg · kg^–1 · min^–1) was started. After a 20-min stabilization period, MAC was again assessed (0.04 mg · kg^–1 · min^–1 landiolol). The infusion of landiolol was then increased from 0.04 to 0.2 mg · kg^–1 · min^–1, and after a 20-min stabilization period, MAC was again assessed (0.2 mg · kg^–1 · min^–1 landiolol). Finally, the infusion of landiolol was stopped, and after a 20-min stabilization period, MAC was assessed for a fourth time (Baseline 2).

RESULTS: Landiolol clearly attenuated the increases in heart rate and mean arterial blood pressure that occurred in response to the dewclaw clamp, but did not alter the MAC of isoflurane.

CONCLUSIONS: Landiolol does not alter the antinociceptive effect of isoflurane. This result, combined with that from our previous work, also suggests that landiolol does not influence the anesthetic potency of inhaled anesthetics.

This article has been cited by other articles:

				T. Kurita, K. Takata, K. Morita, and S. Sato Lipophilic {beta}-adrenoceptor antagonist propranolol increases the hypnotic and anti-nociceptive effects of isoflurane in a swine model Br. J. Anaesth., June 1, 2008; 100(6): 841 - 845. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999