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Dynamics of Local-Anesthetic Compounds in Regional Anesthesia

P. PRITHVI RAJ, MD^*, RICHARD ROSENBLATT, MD, JORDAN MILLER, MD, RONALD L. KATZ, MD, and EDWARD CARDEN, MD^||

* Associate Professor., Department of Anesthesiology, University of California, Los Angeles and Wadsworth Veterans Administration Hospital, Los Angeles, California 90075. Fellow., Department of Anesthesiology, University of California, Los Angeles and Wadsworth Veterans Administration Hospital, Los Angeles, California 90075. Assistant Professor., Department of Anesthesiology, University of California, Los Angeles and Wadsworth Veterans Administration Hospital, Los Angeles, California 90075. Chairman and Professor., Department of Anesthesiology, University of California, Los Angeles and Wadsworth Veterans Administration Hospital, Los Angeles, California 90075. ||Associate Professor., Department of Anesthesiology, University of California, Los Angeles and Wadsworth Veterans Administration Hospital, Los Angeles, California 90075.

Abstract

The clinical effectiveness and safety of compounded mixtures of lidocaine + bupivacaine and chloroprocaine + bupivacaine for either epidural or brachial-plexus block was studied in 48 adult patients. Of the several alternatives, chloroprocaine + bupivacaine with epinephrine was found the best choice for patients with typical plasma cholinesterase.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999