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Anesth Analg 1977; 56:32-34
© 1977 International Anesthesia Research Society
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The Effect of Spontaneous Versus Controlled Ventilation on the Rate of Rise of Alveolar Halothane Concentration in Dogs

ROBERT T. GIBBONS, MD*, EUGENE P. STEFFEY, VMD, PhD{dagger}, and EDMOND I. EGER, II, MD{ddagger}

* Research Trainee. Present address: Department of Anesthesia, St. Luke's Hospital, Kansas City, Missouri 64111., Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143. {dagger}Research Trainee., Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143. {ddagger}RProfessor., Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143.

Abstract

The rate of rise of the alveolar inspired halo-thane concentration (FA/FI) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4 percent. Initially, FA/FI rose at similar rates for all 3 concentrations, but at 4 percent, the plateau attained was lower as a result of respiratory depression. In a 2nd group of dogs, FA/FI was measured for inspired concentrations of 0.3, 1.5, 4, and 6 percent during controlled ventilation. FA/FI rose at similar rates at the lower 2 concentrations but at progressively more rapid rates at inspired concentrations of 4 and 6 percent, presumably as a result of circulatory depression.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.