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Lack of CNS Depression From Large Doses of Trimethaphan in Sheep

K. C. WONG, MD, PhD^*, JEFFREY L. PETERS, PhD, MD, THEODORE S. ROBERTS, MD, JAMES C. McREA, BS, and HIROYUKI FUKUMASU, MD^||

*Associate Professor and Chairman of Anesthesiology, Associate Professor of Pharmacology., University of Utah Medical Center, Salt Lake City, Utah 84132. Associate Research Professor of Bioengineering and Assistant Research Professor of Surgery., University of Utah Medical Center, Salt Lake City, Utah 84132. Associate Professor of Neurosurgery., University of Utah Medical Center, Salt Lake City, Utah 84132. Research Assistant, Department of Surgery., University of Utah Medical Center, Salt Lake City, Utah 84132. ||Visiting Thoracic Surgeon, Department of Surgery, Kyoto University, Kyoto, Japan., University of Utah Medical Center, Salt Lake City, Utah 84132.

Abstract

It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (TALVB) withdrawing blood from the apex of the left ventricle through a roller pump, Pall Ultipor filter, and returning the blood to a carotid artery. In the awake and unanesthetized animals, 1 to 2 gm of trimethaphan were administered IV during each experiment while maintaining mean arterial pressure at 60 to 75 torr. Two sheep stood up and knelt down without obvious correlation with dose of trimethaphan administered at the time; two remained standing and continued eating during the trimethaphan infusion. Cardiovascular recovery from these large doses of trimethaphan was within 15 to 30 minutes after the conclusion of drug infusion. The data strongly suggest that large doses of trimethaphan have no significant CNS depression in the awake and unanesthetized sheep.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999