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Anesth Analg 1977; 56:68-72
© 1977 International Anesthesia Research Society
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Effect of Halothane and Pentobarbital Anesthesia on the Dispersion of Indicator Particles Passing Through the Central Circulation of the Dog

GUY C. DAVIS, JR, MD, PhD*, A. WILLIAM PAULSEN, MMSc{dagger}, and EVAN L. FREDERICKSON, MD{ddagger}

*Research Fellow, Anesthesiology; Clinical Associate, Statistics and Biometry. Present address: Department of Anesthesiology, Duke University, Durham, North Carolina 27710. {dagger}Instructor, Division of Allied Health Sciences., Department of Anesthesiology and the Department of Statistics and Biometry, Emory University, Atlanta, Georgia 30322. {ddagger}Professor, Anesthesiology., Department of Anesthesiology and the Department of Statistics and Biometry, Emory University, Atlanta, Georgia 30322.

Abstract

To investigate the effect of different anesthetics on the flow properties of the central circulation, curves were obtained by the multiple indocyanine-green indicator-dilution technic from 7 dogs anesthetized with halothane or pentobarbital. The width of the curve provided a measure of the dispersion of indicator particles during passage through the central circulation. The vascular resistance of the animals was altered by the administration of methoxamine and sodium nitroprusside. The authors found that dispersion in the central circulation is linearly related to the total peripheral resistance (TPR). For any value of TPR, the amount of dispersion of indicator particles passing through the central circulation was greater with halothane plus pentobarbital anesthesia than with pentobarbital only.

The study indicates that the type of anesthesia influences the dispersion of indicator particles passing through the central circulation. A better understanding of this process will be helpful in interpreting the results of indicator-dilution cardiac-output determinations performed in persons under general anesthesia.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.