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Isoflurane Anesthesia and Pressure Antagonism in Mice

D. W. KENT, MD^*, M. J. HALSEY, DPhil, E. I. EGER, II, MD, and B. KENT

* Research Trainee, Department of Anesthesia, University of California, San Francisco, California 94143. Scientific Staff, Clinical Research Centre, Harrow, Middlesex, England. Professor, Department of Anesthesia, University of California. Laboratory Assistant.

Abstract

The anesthetic partial pressure causing a loss of righting reflex in mice (ED₅₀) was determined for isoflurane at ambient total pressures ranging from 1 to 100 atmospheres absolute (ATA). The higher pressures, produced by adding helium, decreased isoflurane's apparent an esthetic effect: 48 percent more was needed at 100 ATA. This is consistent with previous work with N₂O, where a 46 percent increase was found. The ED₅₀ for isoflurane at 1 ATA is 0.0057 ATA, only 29 percent of that predicted by the Meyer-Overton relationship for mice.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999