JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by KRISHNA, G. Articles by PARADISE, R. R. Search for Related Content PubMed PubMed Citation Articles by KRISHNA, G. Articles by PARADISE, R. R.

Mechanisms of Chronotropic Effects of Volatile Inhalation Anesthetics

GOPAL KRISHNA, MD^*, and RAYMOND R. PARADISE, PhD

*Assistant Professor, Department of Anesthesiology Indiana University School of Medicine, Indianapolis, Indiana 46202. Professor, Departments of Pharmacology and Anesthesiology Indiana University School of Medicine, Indianapolis, Indiana 46202.

Abstract

The chronotropic effects of all currently available volatile anesthetics were investigated in isolated rat atrial preparations. Anesthetic ethers, diethyl ether, methoxyflurane, and enflurane elicited a dose-dependent positive chronotropic effect. Fluroxene produced a slight depression at low concentrations. The halogenated hydrocarbon anesthetics, halothane, chloroform, and trichloroethylene, did not show a uniform pattern. Halothane's effect was small and biphasic. Chloroform caused a dose-dependent decrease in heart rate, and trichloroethylene caused a marked positive chronotropic effect. The dose-response curves of all anesthetics remained unaltered in the presence of either 3 x 10^–7 M dl-propranolol or 1 x 10^–6 M atropine. It is concluded that volatile anesthetics elicit significant direct chronotropic actions on rat atrial preparations. The mechanism of their actions does not involve stimulation of beta-adrenergic or cholinergic receptors.

This article has been cited by other articles:

				H. L. Collins and S. E. DiCarlo Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1020 - H1026. [Abstract] [Full Text] [PDF]

				H. L. Collins, A. M. Loka, and S. E. DiCarlo Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H532 - H540. [Abstract] [Full Text] [PDF]

				H.-H. Chen, Y.-R. Lin, Q.-G. Peng, and M.-H. Chan Effects of Trichloroethylene and Perchloroethylene on Muscle Contractile Responses and Epithelial Prostaglandin Release and Acetylcholinesterase Activity in Swine Trachea Toxicol. Sci., January 1, 2005; 83(1): 149 - 154. [Abstract] [Full Text] [PDF]

				D. W. Rodenbaugh, H. L. Collins, D. G. Nowacek, and S. E. DiCarlo Increased susceptibility to ventricular arrhythmias is associated with changes in Ca2+ regulatory proteins in paraplegic rats Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2605 - H2613. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999