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A Comparison of Glycopyrrolate and Atropine During Reversal of Nondepolarizing Neuromuscular Block with Neostigmine

*Assistant Professor of Anaesthesia, Harvard Medical School; Anesthesiologist, Boston Hospital for Women, Boston, Massachusetts 02115.

Abstract

Glycopyrrolate and atropine were compared as to their effects on heart rate, arrhythmias, blood pressure, and volume of oropharyngeal secretions. Glycopyrrolate protects against neo- stigrnine-induced bradycardia, produces less initial tachycardia, causes a lower incidence of cardiac arrhythmias, and is a superior oropharyngeal drying agent. Use of this drug instead of atropine should be considered during reversal of nondepolarizing neuromuscular block.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999