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Anesth Analg 1977; 56:207-210
© 1977 International Anesthesia Research Society
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Arrhythmic Doses of Epinephrine and Dopamine During Halothane, Enflurane, Methoxyflurane, and Fluroxene Anesthesia in Goats

BEHROOZ ZAHED, MD*, DAVID J. MILETICH, PhD{dagger}, A. D. IVANKOVICH, MD{ddagger}, R. F. ALBRECHT, MD§, and EDWARD T. TOYOOKA, MD*

*Associate Professor of Anesthesiology, Pritzker School of Medicine, The University of Chicago Department of Anesthesiology, Michael Reese Medical Center, Chicago, Illinois 60616. {dagger}Assistant Professor of Anesthesiology, Pritzker School of Medicine, The University of Chicago Department of Anesthesiology, Michael Reese Medical Center, Chicago, Illinois 60616. {ddagger}Professor of Anesthesiology, Abraham Lincoln School of Medicine, The University of Illinois Department of Anesthesiology, Michael Reese Medical Center, Chicago, Illinois 60616. §Professor of Anesthesiology, Pritzker School of Medicine, The University of Chicago; Chairman, Department of Anesthesiology, Michael Reese Medical Center Department of Anesthesiology, Michael Reese Medical Center, Chicago, Illinois 60616.

Abstract

The cardiac arrhythmicity of epinephrine and dopamine was compared in awake goats and during approximate equivalent levels of halothane, enflurane, methoxyflurane, and fluroxene anesthesia. The arrhythmic threshold dose for epinephrine and dopamine was significantly (p<0.05) reduced during halothane anesthesia when compared to values determined in awake animals. Enflurane anesthesia had no significant affect on the arrhythmic threshold dose for either catecholamine. However, methoxyflurane and fluroxene anesthesia significantly (p<0.05) elevated the arrhythmic threshold dose for dopamine. Epinephrine produced greater elevations in mean arterial pressure than dopamine with all anesthetics except enflurane, and dopamine produced significantly (p<0.05) higher heart rates in the awake animals and those anesthetized with halothane and enflurane.

The authors conclude that, in terms of arrhythmic potential, there is no advantage in the use of dopamine rather than epinephrine for the reversal of halothane-induced myocardial depression during halothane or enflurane anesthesia.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.