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Anesth Analg 1977; 56:211-215
© 1977 International Anesthesia Research Society
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Evaluation of Intravenous Diazepam as a Surgical Premedicant

JAMES T. CONNER, MD*, J. WELDON BELLVILLE, MD{dagger}, RONALD H. WENDER, MD{ddagger}, SUSAN WAPNER, RN§, and RONALD L. KATZ, MD||

*Assistant Professor of Anesthesiology Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. {dagger}Professor of Anesthesiology Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. {ddagger}Resident in Anesthesiology Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. §Research Nurse Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. ||Professor of Anesthesiology and Chairman of the Department of Anesthesiology Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024.

Abstract

Intravenous diazepam was administered to 4 groups of 35 patients as a surgical premedicant, double blind and according to a randomized sequence. Four dosages were used: 2.5, 5, 10, and 20 mg. Amnesia, relief of anxiety, sedation, and patient acceptance were primarily evaluated. While a significant linear dose effect was found for sedation, anxiety relief, and patient acceptance, this was not true for amnesia, which was clinically present only with doses of 10 and 20 mg. No significant adverse effects were noted at any dosage, and vital signs remained stable in all patients studied.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.