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*Associate Professor, Department of Anesthesiology (UCLA), Harbor General Hospital Campus, Torrance, California
Professor and Chairman, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024.
Abstract
Trains of neurally evoked compound electro-myographic responses of the thenar muscles were studied in 20 patients anesthetized with enflurane and N2O and paralyzed with d-tubocurarine. Fade was correlated with stimulus frequency (0.1 to 50 Hz) and degree of neuromuscular block. The lowest response in a train occurred on the 4th and the 6th-to-8th responses when the train was elicited at 2 Hz and 50 Hz, respectively. Fade was more observable with deeper block and could best be demonstrated by 5 Hz stimuli. With 50 Hz stimuli, a concomitant facilitation, observable from the beginning of the train, partially compensated for the fade.
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