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Comparative Neuromuscular Effects of Lincomycin and Clindamycin

J. THOMAS RUBBO, MD^*, SAMIR D. GERGIS, MD, and MARTIN D. SOKOLL, MD

*Resident in Anesthesia, Department of Anesthesia, University of Iowa Hospitals, Iowa City, Iowa 52242. Professor of Anesthesia, Department of Anesthesia, University of Iowa Hospitals, Iowa City, Iowa 52242.

Abstract

The effects of lincomycin and clindamycin on neuromuscular transmission in vitro were studied. Standard microelectrode technics were used to measure miniature endplate potential (MEPP) amplitude and frequency, and endplate sensitivity to acetylcholine on the frog sartorius muscle. Twitch tension and nerve terminal acetylcholine release were also studied. In the drug concentration range where twitch tension changes occurred, both drugs caused marked decreases in MEPP amplitude and decreases in endplate sensitivity to iontophoretically applied acetylcholine. Lincomycin did not alter MEPP frequency but decreased acetylcholine release. Clindamycin increased MEPP frequency and increased acetylcholine release. The study shows that both lincomycin and clindamycin cause blockade of neuromuscular transmission through a postsynaptic action. However, at high concentrations, lincomycin has a nerve-terminal depressant effect, while clindamycin has a marked presynaptic stimulatory effect.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999