JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1977; 56:387-390
© 1977 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TANIFUJI, Y.
Right arrow Articles by TERRELL, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TANIFUJI, Y.
Right arrow Articles by TERRELL, R. C.

Some Characteristics of an Exceptionally Potent Inhaled Anesthetic

Thiomethoxyflurane

YASUMASA TANIFUJI, MD*, EDMOND I. EGER, II, MD{dagger}, and ROSS C. TERRELL, PhD{ddagger}

*Research Trainee, Department of Anesthesia, University of California, San Francisco, California 94143. {dagger}Professor, Department of Anesthesia, University of California. {ddagger}Manager, Chemical Product Development, Ohio Medical Products.

Abstract

The authors sought to test whether a deviation existed for the correlation between anesthetic potency and the oil/gas partition coefficient at an extreme of lipid solubility. For thiomethoxyflurane, the sulfur analog of methoxyflurane, the oil/gas partition coefficient was 7230 ± 50 SEM, and MAC (minimum alveolar concentration of thiomethoxyflurane required for anesthesia) in 4 dogs was 0.035 ± 0.008 percent of 1 atm. This agrees with the potency predicted by the lipid solubility, although thiomethoxyflurane is 71/2 times more potent than methoxyflurane, to date the most potent available anesthetic. Thiomethoxyflurane water/gas and blood/gas partition coefficients were 5.4 ± 0.3 and 68.1 ± 1.5, respectively. The latter coefficient accords with the prolonged recovery associated with this agent. Renal and hepatic blood chemistries measured on the 1st and 7th days following anesthesia showed only small changes from preanesthetic values.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Rajaram, M. M. Sedensky, and P. G. Morgan
unc-1: A stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans
PNAS, July 21, 1998; 95(15): 8761 - 8766.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.