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Ketamine Anesthesia in Dermolytic Bullous Dermatosis (Epidermolysis Bullosa)

S. R. LoVERME, MD, FACS^*, and A. T. OROPOLLO, MD, FACA

*Clinical Professor of Plastic and Reconstructive Surgery, New Jersey College of Medicine and Dentistry, Newark, New Jersey 07102. Director, Department of Anesthesia, Montclair Community Hospital, Montclair, New Jersey.

Abstract

An unusual hereditary disease entity of the integument, dermolytic bullous dermatosis (epidermolysis bullosa dystrophica), recessive type, is presented. The disease is characterized by the formation of bullae, vesicles, and erosions upon the application of the least trauma. Healing results in scarring and incapacitating deformities which require extensive reconstructive surgery.

A technic utilizing ketamine-diazepam "dissociative anesthesia" for several surgical procedures for this condition is described. The technic enabled the patient to undergo 3 complex operations over a 2-year period with minimum complications.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999