JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by CONNER, J. T. Articles by KATZ, R. L. Search for Related Content PubMed PubMed Citation Articles by CONNER, J. T. Articles by KATZ, R. L.

Morphine, Scopolamine, and Atropine as Intravenous Surgical Premedicants

JAMES T. CONNER, MD^*, J. WELDON BELLVILLE, MD, RONALD WENDER, MD, DONNA SCHEHL, RN, FREDERICK DOREY, MD^||, and RONALD L. KATZ, MD^**

*Assistant Professor of Anesthesiology, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977 Professor of Anesthesiology, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977 Resident in Anesthesiology, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977 Research Nurse, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977 ||Statistician in Biomathematics, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977 **Professor and Chairman, Department of Anesthesiology, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. Accepted for publication: January 28, 1977

Abstract

Morphine (5 and 10 mg), scopolamine (0.4 mg), and atropine (0.4 mg), alone and in combination, were studied as IV premedicants in 240 surgical patients. Relief of anxiety and sedation as compared to the patient's unpremedi-cated state were evaluated by the patient and a trained nurse observer, respectively, at 15 and 30 minutes after injection. Lack of recall was tested by the showing of memory cards at 15 and 30 minutes and by the recall of entering the operating room. Patient acceptance of the medications and recall were then evaluated 24 hours after injection. For relief of anxiety, sedation, and patient acceptance, scopolamine scored higher than atropine alone. Morphine with atropine or scopolamine scored higher than morphine alone, with morphine plus scopolamine scoring higher than morphine plus atropine. No lack of recall was seen in patients receiving atropine alone or with morphine. Slight lack of recall was seen with scopolamine and was not altered by the addition of morphine. Side effects were greatest with patients receiving morphine and greater with scopolamine than with atropine. Patients receiving scopolamine with general anesthesia tended to sleep longest in the recovery room.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999