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Crystalloid Hemodilution, Hypothermia, and Halothane Blood Solubility During Cardiopulmonary Bypass

Associate Professor of Anesthesiology, University of Miami School of Medicine, Miami, Florida 33152.

Abstract

Sequential determinations of halothane blood solubility were determined in 8 patients undergoing cardiac surgical procedures with cardiopulmonary bypass (CPB), hypothermia, and crystalloid hemodilution.

The mean temperature-corrected blood/gas partition coefficient (B/G) at the end of surgery (2.4) was lower than preceding induction (2.7). The greatest mean B/G (2.9) occurred after induction of anesthesia. The halothane B/G did not increase significantly at the inception of CPB but decreased from a mean of 2.7 to 1.6 as the patients were rewarmed. The maximum range of B/G for a single patient was 1.4 to 3.1. For halothane, the increased blood solubility due to hypothermia was initially antagonized by the crystalloid hemodilution. This antagonism would also be anticipated for methoxyflurane, enflurane, and isoflurane. For N₂O and diethyl ether, the increased blood solubility due to hypothermia would be unopposed by simultaneous crystalloid hemodilution

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999