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Anesth Analg 1977; 56:674-677
© 1977 International Anesthesia Research Society
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Nausea and Vomiting After Anesthesia and Minor Surgery

T. J. WINNING, FFARCS(Eng)*, J. G. BROCK-UTNE, FFA (SA)*, and J. W. DOWNING, FFARCS(Eng){dagger}

*Senior Anaesthetist, King Edward Hospital, Department of Anaesthetics, Faculty of Medicine, University of Natal, Congella, Durban, 4013, South Africa. {dagger}Professor and Head, Department of Anaesthetics, Department of Anaesthetics, Faculty of Medicine, University of Natal, Congella, Durban, 4013, South Africa.

Abstract

The antiemetic effects of droperidol, diphenidol, and placebo were compared in 210 patients subjected to minor gynecologic or urologic procedures. Atropine (0.6 mg), meperidine (1 mg/ kg) body mass, and either droperidol (5 mg), diphenidol (40 mg), or 2 ml of 0.9% saline were administered IM, 1 hour before general anesthesia. Trial drugs were presented in coded ampules so that the study was conducted double-blind. Droperidol appeared superior to both diphenidol (p<0.01) and placebo (p<0.001) in the prevention of vomiting, and reduced the incidence of nausea when compared to saline (p<0.05). Forty-four patients experienced side effects, which occurred with similar frequency in the 3 groups studied.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.