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Anesth Analg 1977; 56:817-821
© 1977 International Anesthesia Research Society
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Cerebral Surface pH Changes During Asphyxia, Hypotension, and Circulatory Arrest in the Dog

A. E. YOUNG, FRCS*, V. FENCL, MD{dagger}, M. WOODS, MD{ddagger}, J. DMOCHOWSKI, MD§, and N. P. COUCH, MD, FACS||

*Research Fellow; recipient of a grant from the Wellcome Foundation. {dagger}Associate Professor of Physiology (Anesthesia). {ddagger}Research Fellow. §Associate in Surgery. ||Associate Professor of Surgery. Departments of Surgery and Anesthesia, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts.

Abstract

A technic is described for the measurement of cerebral surface pH in acute experiments in anesthetized dogs. During asphyxia and circulatory arrest, cerebral surface pH fell promptly and more profoundly than arterial blood or muscle surface pH; during hypovolemic hypotension (30 to 50 torr) cerebral surface pH declined later and less than muscle surface pH. The cerebral surface pH reflects the pH of the cortical interstitial fluid. Since the blood brain barrier is effectively impermeable to lactate, the changes recorded in the cerebral surface pH are a useful index of cortical intracellular metabolism.

Key Words: ACID-BASE EQUILIBRIUM, pH • BRAIN, pH • HYPOXIA, pH • MEASUREMENT, cerebral pH






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.