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Anesth Analg 1977; 56:826-830
© 1977 International Anesthesia Research Society
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Age, Chronic Obstructive Pulmonary Disease, and Innovar®. Induced Ventilatory Depression During Regional Anesthesia

MICHAEL F. MULROY, II, MD, JEROME H. B. COOMBS, MB, MICHAEL D. ISENBERG, MD, and H. BARRIE FAIRLEY, MB

Department of Anesthesia, University of California, San Francisco, San Francisco General Hospital, San Francisco, California 94110.

Abstract

The effect of Innovar® on ventilatory response to COs was studied in 35 patients undergoing peripheral surgery with regional anesthesia. The dosage schedule (per 70 kg hody weight) was 2 ml intramuscularly, prior to the block, and 1 ml intravenously, after the block. The decrease in mean CO2 response slope (15 percent decrease from control 30 minutes after the first dose) was not statistically significant. Control slope varied inversely with age (r = 0.41, p<0.05), and (in 22 patients) directly with the FEV1/FVC ratio (r = 0.54, p<0.02) and with the combined variables (FEV1/FVC)/age (r = 0.58, p<0.01). Depression of CO2 response slope following Innovar did not vary with age or FEV1. We conclude that, in otherwise normal patients, these doses of Innovar cause only minor depression of ventilatory response to CO2. However, in those patients who already have a depressed response (the elderly and those with a decreased FEV1/FVC ratio), this additional depression occasionally may be clinically important.

Key Words: ANESTHETICS, intravenous, Innovar • VENTILATION, Innovar • AGE, ventilation






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.