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Anesth Analg 1977; 56:847-851
© 1977 International Anesthesia Research Society
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Intermittent Exposure to 40 Percent Oxygen Prolongs Rat Survival in 100 Percent Oxygen

ROLAND D. PAEGLE, MD*, WILLIAM N. BERNHARD, MD{dagger}, and HERMAN TURNDORF, MD{ddagger}

*Director of Pathology Residency Training and Research Program, Perth Amboy General Hospital, Perth Amboy, New Jersey; Associate Professor of Clinical Pathology, New York University Medical Center, New York, New York. {dagger}Associate Professor, Department of Anesthesiology, New York University Medical Center. {ddagger}Professor and Chairman, Department of Anesthesiology, New York University Medical Center.

Abstract

Prior intermittent exposure to 40 percent O2 protected rats against fatal O2 toxicity. Protection was not absolute, however, for the death of most rats in 100 percent O3 was not prevented but delayed considerably. Furthermore, those rats which did survive exposure to 100 percent O2 for long periods by virtue of prior adaptation to increased O2 concentrations had pathologic changes in the lungs typical of chronic O2 toxicity. The very early demise of some rats indicated that 1 of 12 animals is hypersensitive to high concentrations of inspired O2.

Key Words: OXYGEN, toxicity






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1977 by the International Anesthesia Research Society.