JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Carlon, G. C. Articles by Goldiner, P. L. Search for Related Content PubMed PubMed Citation Articles by Carlon, G. C. Articles by Goldiner, P. L.

Rapid Volume Expansion in Patients with Interstitial Lung Diseases

Graziano C. Carlon, MD^*, Roberta C. Kahn, MD, Giancarlo Bertoni, MD, Phyllis B. Campfield, RN, William S. Howland, MD^||, and Paul L. Goldiner, MD^¶

*Co-director, Intensive Care Unit, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Clinical Assistant Attending, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Fellow, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Physiologic Profiles Technician, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. ||Chairman, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. ¶Associate Chairman, Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021.

Abstract

Rapid administration of intravascular volume expanders is often necessary during anesthesia. Significant controversy still exists on the relative values of different volume expanders. Fifteen hypoxemic patients (Pa₀₂ <70 torr on room air) were studied preoperatively. They were randomized into three groups. One group received 1.5 ml/kg of 25% salt-poor human albumin, a second group, 7 ml/kg of fresh frozen plasma; a third group, 7 ml/kg of 0.9% NaCI in water (normal saline). The infusions were given intravenously and completed in 20 minutes. Changes in hemodynamic pressures and flows, blood chemistries, and oxygen uptake and transport variables were studied. It was concluded that fresh frozen plasma afforded the greatest increase in cardiac output and oxygen availability with the least increase in left ventricular stroke work. Colloid osmotic pressure was more significantly increased by fresh frozen plasma than by salt-poor human albumin. Normal saline caused both a decrease in oxygen availability and colloid osmotic pressure. Pulmonary venous admixture increased to some extent in all patients receiving fresh frozen plasma or normal saline. In three patients, this increase was very marked and accompanied by severe arterial hypoxemia.

Key Words: BLOOD, Volume: expansion • FLUID BALANCE: volume expansion • PROTEIN: albumin, salt poor • BLOOD, plasma

This article has been cited by other articles:

				M. M. Wilkes and R. J. Navickis Patient Survival after Human Albumin Administration: A Meta-Analysis of Randomized, Controlled Trials Ann Intern Med, August 7, 2001; 135(3): 149 - 164. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999