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Management of Suspected Malignant Hyperpyrexia in an Infant

David K. Faust, MD^*, Samir D. Gergis, M.D., and Martin D. Sokoll, M.D.

*Resident in Anesthesia, Department of Anesthesia, University of Iowa Hospitals, Iowa City, Iowa 52242. Professor of Anesthesia, Department of Anesthesia, University of Iowa Hospitals, Iowa City, Iowa 52242.

Abstract

A case of possible malignant hyperthermia in a 6-month-old child is presented. Malignant hyperthermia was manifested in this patient by persistent metabolic acidosis in the intraoperative and postoperative periods, by a rapid rise in temperature with concomitant unresponsiveness in the postoperative period, and by a positive caffeine-halothane stimulation test. The malignant hyperthermia occurring in the postoperative period resolved promptly following administration of dantrolene sodium. An unusual aspect of this case is that both of the child's parents had normal CPK values and negative caffeine-halothane stimulation tests.

Key Words: HYPERTHERMIA: Malignant pyrexia

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999