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Anesth Analg 1979; 58:36-39
© 1979 International Anesthesia Research Society
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Failure of Naloxone and Naltrexone to Antagonize Halothane Anesthesia in the Dog

Nathan L. Pace, MD*, and K. C. Wong, MD, PhD{dagger}

*Assistant Professor of Anesthesiology, Department of Anesthesiology, University of Utah College of Medicine, Salt Lake City, Utah 84132. {dagger}Professor and Chairman of Anesthesiology, Department of Anesthesiology, University of Utah College of Medicine, Salt Lake City, Utah 84132.

Abstract

The effects of two narcotic antagonists, naloxone and naltrexone, on minimum alveolar anesthetic concentration (MAC) were studied during halothane anesthesia in the dog. Following induction of anesthesia, MAC was determined in duplicate. Each dog was then given one of the two narcotic antagonists and MAC was redetermined in duplicate: five dogs were given naloxone, 3 mg/kg IV, followed by an intravenous infusion of naloxone, 0.025 mg/kg/min; five dogs received naltrexone, 5 mg/kg IV. MAC was unaffected by the narcotic antagonists. Failure of narcotic antagonists to reverse halothane anesthesia suggests that the endogenous opioid peptides are not involved in the anesthetic state produced by halothane.

Key Words: ANTAGONISTS, Narcotic: naloxone • ANTAGONISTS, Narcotic: naltrexone • ANESTHETICS, Volatile: halothane




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.