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Defect in Oxygenation Associated with Mannitol

R. Richard Edde, MD^*, and Saundra Smalley, CRNA

*Assistant Professor, Department of Anesthesiology, The University of Oklahoma Health Sciences Center and Veterans Administration Hospital, Oklahoma City, Oklahoma. Department of Anesthesiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190. Nurse Anesthetist, Veterans Administration Hospital. Department of Anesthesiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190.

Abstract

Mannitol is an osmotic diuretic used during intracranial surgical procedures to reduce brain size and thereby to improve operating conditions. It is distributed in the extracellular fluid and therefore can be accompanied by an acute expansion of extracellular fluid volume.¹ This may have a detrimental effect on arterial oxygenation as illustrated by the following patients.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999