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Serum Cholinesterase Levels in Patients with Cancer

P. Kaniaris, MD, MSc, DA^*, A. Fassoulaki, MD, MSc, K. Liarmakopoulou, MD, and E. Dermitzakis, MD, MSc

*Associate in Pharmacology, Acting Head of Anesthesiology, Medical School, University of Athens. Department of Experimental Pharmacology and the Division of Anesthesiology, Medical School, University of Athens, and the Department of Anesthesiology, Hellenic Anticancer Institute, Saint Savas Hospital, Athens, Greece. Research Assistant, Department of Experimental Pharmacology, University of Athens. Department of Experimental Pharmacology and the Division of Anesthesiology, Medical School, University of Athens, and the Department of Anesthesiology, Hellenic Anticancer Institute, Saint Savas Hospital, Athens, Greece. Director of Anesthesiology, Hellenic Anticancer Institute, Saint Savas Hospital Athens. Department of Experimental Pharmacology and the Division of Anesthesiology, Medical School, University of Athens, and the Department of Anesthesiology, Hellenic Anticancer Institute, Saint Savas Hospital, Athens, Greece.

Abstract

Serum cholinesterase levels were determined in 180 patients with carcinoma and in 146 normal subjects. Serum cholinesterase activity was significantly lower in patients suffering from cancer than in normal controls, though still within the normal range. The degree of depression of serum cholinesterase activity was influenced by the extent to which the malignancy had spread and by the site of the primary lesion.

Key Words: ENZYMES: cholinesterase • CANCER: serum cholinesterase.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999