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Anesth Analg 1979; 58:85-87
© 1979 International Anesthesia Research Society
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Analgesic Properties of Lidocaine in Mice

Paul A. Moore, DMD, PhD*, and Robert G. Burney, MD{dagger}

*Postdoctoral Fellow, Pain Center, Dental Research Center, The University of North Carolina. Pain Center, Dental Research Center, The University of North Carolina, Chapel Hill, North Carolina 27514. {dagger}Associate Professor of Anesthesiology, Department of Anesthesiology, North Carolina Memorial Hospital. Pain Center, Dental Research Center, The University of North Carolina, Chapel Hill, North Carolina 27514.

Abstract

The analgesic properties of lidocaine and morphine were compared in mice using a hot plate stimulus. An analgesic response was defined as an increase in the time required for an animal to attempt to escape by jumping. When compared to saline-treated controls, lidocaine produced a statistically significant dose-related delay in response to heat. Dose-response curves for morphine and lidocaine indicated that morphine has greater potency and efficacy. Naloxone (1.0 mg/kg) reversed the analgesic response due to morphine (10 mg/kg) but had no effect on the analgesia produced by lidocaine (50 mg/kg).

Key Words: ANESTHETICS, Local: lidocaine • ANTAGONISTS, Narcotic: naloxone.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.