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Gastric Excretion of Intravenously Administered Meperidine in Surgical Patients

R. J. Trudnowski, MD^*, and T. Gessner, PhD

*Chief, Department of Anesthesiology. Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, Buffalo, New York 14263. Associate Cancer Research Scientist, Department of Experimental Therapeutics. Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, Buffalo, New York 14263.

Abstract

We have demonstrated sequestration of unchanged meperidine in gastric juice of humans following intravenous administration. Concentrations attained were as great as 360 times plasma concentration. The drug was first detected between 5 and 15 minutes after administration. This phenomenon appears to be due to ionization and ion trapping of meperidine in gastric juice.

Key Words: ANALGESICS, Narcotic: meperidine • PHARMACOKINETICS: meperidine • GASTROINTESTINAL TRACT: stomach.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999