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Anesth Analg 1979; 58:93-98
© 1979 International Anesthesia Research Society
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Naloxone Fails to Antagonize Halothane-Induced Depression of the Longitudinal Muscle of the Guinea Pig Ileum

Yoshitomo Shiwaku, MD*, Hideo Nagashima, MD{dagger}, Richard M. Duncalf, BS{ddagger}, Deryck Duncalf, MD§, and Francis Foldes, MD|

*Associate Professor, Department of Anesthesiology, Okayama University School of Medicine, Okayama, Japan. Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York, 10467. {dagger}Director, Anesthesiology Research, Montefiore Hospital and Medical Center; Associate Professor of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York. Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York, 10467. {ddagger}Research Fellow in Anesthesiology, Montefiore Hospital and Medical Center. Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York, 10467. §Chairman, Department of Anesthesiology, Montefiore Hospital and Medical Center; Professor of Anesthesiology, Albert Einstein College of Medicine. Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York, 10467. |Consultant in Anesthesiology, Montefiore Hospital and Medical Center, Emeritus Professor, Albert Einstein College of Medicine. Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York, 10467.

Abstract

The influence of halothane, or naloxone, or halothane followed by naloxone was investigated in the in vitro myenteric plexus longitudinal muscle preparation of the guinea pig ileum. Halothane alone in 1.5 to 2.0% (v/v) concentration caused about 50% depression of the twitch and decreased both spontaneous acetylcholine (ACh) release (p < 0.02) and volley output of ACh (p < 0.02). Very high concentrations (>1 µM) of naloxone caused a nonspecific, postsynaptic depression of the twitch. Higher than 100 nM concentrations of naloxone increased spontaneous ACh release, but had no effect on the volley output of ACh. Over a wide concentration range, from 15 nM to 3 µM, naloxone did not antagonize in the longitudinal muscle preparation the effects of halothane on any of the parameters investigated. These findings indicate that the sites of action of halothane and naloxone in this preparation are not identical.

Key Words: ANTAGONISTS, Narcotic: naloxone • ANESTHETICS, Volatile: halothane.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.