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Anesth Analg 1979; 58:99-103
© 1979 International Anesthesia Research Society
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Failure of Lidocaine to Trigger Porcine Malignant Hyperthermia

Daniel W. Wingard, MD*, and Stephen Bobko, MA, CRNA{dagger}

*Professor and Chairman, Department of Anesthesiology, The University of Nebraska Medical Center. Department of Anesthesiology, The University of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105. {dagger}Lieutenant Colonel, USAF Hospital, Langley Air Force Base, Hampton, Virginia 23665. Department of Anesthesiology, The University of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105.

Abstract

Lidocaine, considered by some to be potentially dangerous in malignant hyperthermia (MH), was administered intravenously to a dose of 15 mg/kg to five conscious MH-susceptible pigs. Subsequently the same pigs were given 24 mg/kg intravenously over a period of 2 hours after being anesthetized with thiopental. All animals developed systemic toxicity to lidocaine but without evidence of MH. Prior administration of lidocaine did not prevent development of subsequent MH due to succinylcholine and halothane. Lidocaine is safe in porcine MH.

Key Words: HYPERTHERMIA: malignant pyrexia • ANESTHETICS, Local: lidocaine.




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P. M. Hopkins
Malignant hyperthermia: advances in clinical management and diagnosis
Br. J. Anaesth., July 1, 2000; 85(1): 118 - 128.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.