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Sodium Nitroprusside

Hernodynamic Dose-Response during Enflurane and Morphine Anesthesia

Assistant Clinical Professor. Department of Anesthesiology, Columbia College of Physicians and Surgeons, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.

Abstract

To date there has been no description of the hemodynamic dose-response relationship betweeO enflurance and sodium nitroprusside (SNP), although these drugs are often used together to induce deliberate hypotension. Utilizing aortic root cannulation and thermistor-tipped pulmonary artery catheters, this relationship was studied in six beagles during 1 and 2% enflurane anesthesia and compared with the hemodynamic response induced by SNP in the awake state and during anesthesia with intravenous morphine (6 µg/kg). Each animal received a standard infusion of 100 µg/kg of SNP administered at three different flow rates (5, 10, and 20 µg/kg/min). SNP infusion resulted in dose-related reductions in mean arterial pressure, systemic vascular resistance and left ventricular stroke work, whereas cardiac output increased. Enflurane potentiated the hypotensive effects of SNP in a dose-related fashion. During morphine anesthesia, however, the hemodynamic effects of SNP were virtually indistinguishable from those observed in the awake state.

Key Words: ANESTHETIC TECHNIQUES, Induced hypotension: nitroprusside • ANESTHETICS, Volatile: enflurane • ANESTHETICS, Intravenous: morphine

This article has been cited by other articles:

				N. Shah, O. DelValle, R. Edmondson, J. Zaccari, R. Bedford, and H. Herr Esmolol or Sodium Nitroprusside for Induced Hypotension During Isoflurane Anesthesia Vascular and Endovascular Surgery, November 1, 1993; 27(9): 681 - 687. [Abstract] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999