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Anesth Analg 1979; 58:189-194
© 1979 International Anesthesia Research Society
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Cardiovascular Effects of Benzquinamide

David J. Smith, PhD*, Jeanne M. Rushin, BS{dagger}, Pedro R. Urquilla, MD{ddagger}, Chang W. Rhee, MD§, Hang J. Yoon, MD§, Fred A. Simpson, MT||, Thara Srichomkuan, MD§, Hak S. Lee, MD§, and Richard B. Knapp, MD

*Associate Professor of Anesthesiology and Pharmacology. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506 {dagger}Medical Student. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506 {ddagger}Associate Professor of Pharmacology. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506 §Resident in Anesthesiology. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506 ||Research Assistant. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506 ¶Professor and Chairman of Department of Anesthesiology. Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506

Abstract

The cardiovascular effects of benzquinamide were evaluated in anesthetized dogs. Intravenous benzquinamide, 0.5 to 5 µg/kg, caused tachycardia, elevated blood norepinephrine levels, frequent ventricular arrhythmias, and brief hypotension. Ganglionic blockade by hexamethonium prior to administration of benzquinamide prevented the tachycardia and alterations in norepinephrine levels but prolonged the period of hypotension. In isolated mesenteric arterial preparations benzquinamide interfered with contractile force generated by potassium chloride, norepinephrine, and prostaglandin F2{alpha}. It is concluded that benzquinamide directly relaxes vascular smooth muscle thereby producing in vivo reduced peripheral vascular resistance and hypotension, which are compensated for by reflex sympathetic activation.

Key Words: VOMITING, Antiemetics: benzquinamide • ATARACTICS: benzquinamide






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.