JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Loarie, D. J. Articles by White, A. Search for Related Content PubMed PubMed Citation Articles by Loarie, D. J. Articles by White, A.

The Hernodynamic Effects of Halothane in Anemic Dogs

Donald J. Loarie, MD^*, Philip Wilkinson, MB, BS, John Tyberg, MD, PhD, and Anne White, MS

*Research Fellow, Cardiovascular Research Institute. Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 Assistant Professor of Anesthesia. Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 Assistant Professor of Cardiology. Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 Staff Research Associate. Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143

Abstract

Hemodynamic dose-response curves and MAC, apneic and lethal concentrations for halothane were determined in two groups of dogs at a normal hematocrit (Hct) (39 ± 6), and during acute anemia (n = 4) and subacute anemia (n = 41, with a combined Hct of 18 ± 6. The ratio of subendocardial/subepicardial blood flow was determined by the injection of radioactive microspheres.

MAC, apneic, and lethal concentrations of halothane were not significantly different in anemic animals. There were also no differences in the halothane dose-response curves plotted for cardiac output, blood pressure, heart rate, left ventricular end-diastolic pressure, or arterial base excess. In 32 microsphere injections with Hct as low as 13, no dog had redistribution of myocardial blood flow suggestive of subendocardial ischemia. We conclude that halothane is a safe anesthetic during severe anemia.

Key Words: BLOOD: anemia • ANESTHETICS, Volatile: halothane

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999