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Anesth Analg 1979; 58:279-287
© 1979 International Anesthesia Research Society
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Alcohol-Induced Pituitary Adenolysis

How Does It Control Intractable Cancer Pain?—An Experimental Study Using Tooth Pulp-Evoked Potentials in Rhesus Monkeys

Hisashi Yanagida, MD*, Guenter Corssen, MD{dagger}, Richardo Ceballos, MD{ddagger}, and Edward Strong, BS§

*Anesthesiologist in Chief, Yokohama Teishin Hospital, Yokohama, Japan. {dagger}Professor, Department of Anesthesiology, University of Alabama in Birmingham. Presently: Chairman, Department of Anesthesiology, Maricopa County General Hospital, Phoenix, Arizona, 85008. {dagger}Professor, Department of Pathology, University of Alabama in Birmingham §Chief, Neurology Research Division, University of Alabama in Birmingham. Departments of Anesthesiology and Pathology and Neurology Research Division, University of Alabama in Birmingham, Birmingham, Alabama.

Abstract

The mechanism by which chemical hypophysectomy may relieve intractable pain in patients with cancer was evaluated in six adult rhesus monkeys. Pain was produced by electrical stimulation of the tooth pulp, and evoked potentials were recorded from the primary somatosensory cortex (PSC), the centrum medianum of the thalamus (CM), and the midbrain reticular formation (MRF) before and after injection of absolute alcohol into the pituitary gland and again following intramuscular administration of naloxone. At autopsy pituitary ablation was found to be complete in three animals and incomplete in the other three. A marked decrease in amplitude without change in latency was observed in the PSC, CM, and MRF in all animals following tooth pulp stimulation, indicating that the hypophysectomy was equally effective regardless of the degree of destruction of the pituitary gland. Naloxone reversed the hypophysectomy-induced changes in tooth pulp-evoked potentials (TPEPs) recorded from PSC in animals with complete destruction of the pituitary but had no effect in any animals on TPEPs recorded from CM and MRF and had no effect on TPEPs recorded from PSC in animals with incomplete destruction of the pituitary. These findings are compatible with the possibility that interference with sensory pathways produced by injection of alcohol may be a causative factor in the decrease in TPEPs recorded and suggest that overproduction of endorphine activated by alcohol-induced hypophysectomy may contribute to the relief of pain in patients with cancer following chemical hypophysectorny.

Key Words: PAIN: hypophysectomy • BRAIN: pituitary






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.