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Anesth Analg 1979; 58:293-296
© 1979 International Anesthesia Research Society
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Platelet Aggregation during and after General Anesthesia and Surgery

Karen M. Lichtenfeld, MD*, Charles A. Schiffer, MD*, and Martin Helrich, MD{dagger}

*Cell Component Therapy Section, Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute. {dagger}Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland. Baltimore Cancer Research Center, 22 South Greene Street, Baltimore, Maryland 21201.

Abstract

Because of evidence suggesting that volatile anesthetics interfere with platelet aggregation in vitro, platelet function was investigated in patients exposed to combinations of nitrous oxide, halothane, and enflurane during brief surgical procedures. In 12 patients undergoing elective operations, blood was sampled before anesthesia, after induction but prior to surgery, during surgery, and postoperatively. Platelet aggregation by ADP, epinephrine, and collagen was similar during each sampling period in all but two subjects in whom only minor changes were noted. During brief exposure to these general anesthetics, there appears to be no clinically important inhibition of platelet function.

Key Words: BLOOD: platelet aggregation




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.