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Anesth Analg 1979; 58:314-317
© 1979 International Anesthesia Research Society
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Effects of Diazepam on Succinylcholine-Induced Myalgia, Potassium Increase, Creatine Phosphokinase Elevation, and Relaxation

Maryellen Eisenberg, CRNA*, Sharon Balsley, CRNA*, and Ronald L. Katz, MD{dagger}

*Instructor, UCLA School of Nurse Anesthesia, Los Angeles, California 90025. {dagger}Professor and Chairman, Department of Anesthesiology, UCLA School of Medicine. University of California, Los Angeles School of Medicine, Los Angeles, California 90024.

Abstract

Diazepam in a dose of 0.05 mg/kg was studied to determine its effect on a subsequently administered dose of 1 mg/kg of succinylcholine. This dose of diazepam prior to succinylcholine (1) significantly diminished the incidence of postoperative muscle pain; (2) decreased the usual increase in serum potassium; (3) did not prevent the rise in creatine phosphokinase; (4) reduced the incidence of muscle fasciculation; and (5) did not affect the magnitude or duration of the succinylcholine neuromuscular block. It was concluded that diazepam had several advantages over d-tubocurarine in the prevention of succinylcholine-induced muscle pain.

Key Words: HYPNOTICS, Benzodiazepines: diazepam • NEUROMUSCULAR RELAXANTS: succinylcholine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.