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Anesth Analg 1979; 58:318-321
© 1979 International Anesthesia Research Society
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Local Anesthetics and Pulmonary Venous Admixture in Pregnant and Nonpregnant Sheep

Egon Lanz, MD*, Bruce Ruiz{dagger}, and Helene Schlereth{ddagger}

*Visiting Assistant Professor of Anesthesiology. Research was performed while Dr. Lam was on sabbatical leave from the Universität Mainz. {dagger}Assistant in Anesthesiology. Departments of Anesthesiology and Obstetrics and Gynecology of the University of Florida College of Medicine, Gainesville, Florida and the lnstitut für Anästhesiologie der Universität, Maim, West Germany. {dagger}Visiting Certified Nurse Anesthetist. Departments of Anesthesiology and Obstetrics and Gynecology of the University of Florida College of Medicine, Gainesville, Florida and the lnstitut für Anästhesiologie der Universität, Maim, West Germany.

Abstract

Pulmonary venous admixture (Formula xs/Formula xt) was determined in nine nonpregnant sheep and in seven pregnant sheep during their last trimesters of gestation. Pulmonary venous admixture was greater in the pregnant animals (5.7 ± 1.6% of the cardiac output; mean ± SD) than in the nonpregnant ones (4.2 ± 1.3% p < 0.05). On consecutive days, four local anesthetics were infused in random order via a femoral venous catheter into each sheep for 30 minutes. Total doses of 1.8 mg/kg of bupivacaine, 2.7 mg/kg of etidocaine, 6 mg/kg of lidocaine, and 15 mg/kg of chloroprocaine were administered. None of the anesthetics induced a significant change in pulmonary venous admixture.

Key Words: ANESTHESIA: obstetric • ANESTHETIC TECHNIQUES: regional • ANESTHETICS: local • PREGNANCY: pulmonary venous admixture • LUNG: shunting






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.