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Anesth Analg 1979; 58:364-366
© 1979 International Anesthesia Research Society
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Duration of Bupivacaine Intradermal Anesthesia When the Bupivacaine Is Mixed with Chloroprocaine

Jong-Min Kim, MD*, Hiroshi Goto, MD{dagger}, and Kasumi Arakawa, MD{ddagger}

Department of Anesthesiology, University of Kansas College of Health Sciences, 39th and Rainbow Blvd, Kansas City, Kansas 66103.

Abstract

In a double-blind trial in 20 human volunteers, the duration of intradermal anesthesia with a mixture of bupivacaine, 0.5 mg, and Chloroprocaine, 3 mg, was compared with the duration of intradermal anesthesia obtained with either bupivacaine, 0.5 mg, or Chloroprocaine, 3 mg, alone. The duration of intradermal anesthesia produced by the bupivacaine mixed with Chloroprocaine, 36 ± 16 (mean ± 1 SD) minutes, was significantly less than the duration of the same amount of bupivacaine alone, 139 ± 78 minutes. Duration of anesthesia with Chloroprocaine alone, 24 ± 11 minutes, was similar to the duration of anesthesia with Chloroprocaine plus bupivacaine. A possible explanation for these results is that bupivacaine competes with Chloroprocaine for nonspecific receptors at the biophase and in the surrounding nerve tissue.

Key Words: ANESTHETICS, Local: bupivacaine • ANESTHETICS, Local: Chloroprocaine • INTERACTIONS (DRUG): local anesthetics • ANESTHESIA, Duration: local anesthetics






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.