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Anesth Analg 1979; 58:387-389
© 1979 International Anesthesia Research Society
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Depression of Lung Mucociliary Clearance by Thiopental and Halothane

A. R. Forbes, MB, ChB, FFARCS*, and G. Gamsu, MD{dagger}

Departments of Anesthesia and Radiology, University of California, San Francisco and Veterans Administration Hospital, 42nd Avenue and Clement, San Francisco, California 94121.

Abstract

It has previously been demonstrated that an induction dose of thiopental, 25 mg/kg, without continuing anesthesia did not depress peripheral lung mucociliary clearance in the dog, whereas 2 hours of anesthesia with halothane, 1.2 MAC, did depress clearance. To determine whether this was because thiopental depresses the mucociliary apparatus less than halothane, this study compared mucociliary clearance after 2 hours of anesthesia with halothane with clearance after 2 hours of anesthesia with thiopental, 40 mg/kg. With thiopental, 40 mg/kg, 50% mucociliary clearance of tantalum from peripheral airways required 280 ± 65 (SEM) minutes, which was comparable to clearance obtained with halothane, 1.2 MAC, 382 ± 27 (SEM) minutes. Hence, thiopental depresses mucociliary clearance as much as halothane does when both are administered in equivalent anesthetic doses for equal periods of time.

Key Words: LUNG: bronchus • ANESTHETICS, Volatile: halothane • ANESTHETICS, Intravenous: thiopental




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1979 by the International Anesthesia Research Society.