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Anesth Analg 1986; 65:507-510
© 1986 International Anesthesia Research Society
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The Effects of Nicardipine on Cerebrospinal Fluid Pressure in Humans

Toshiaki Nishikawa, MD, Keiichi Omote, MD, Akiyoshi Namiki, MD, PhD, and Takeo Takahashi, MD, PhD

Received from the Department of Anesthesiology, Sapporo Medical College and Hospital, Sapporo, Japan.

Abstract

The effects of nicardipine hydrochloride, a calcium channel Mocker, upon cerebrospinal fluid pressure (CSFP) were investigated in 47 patients without intracranial pathology who were assigned to one of three groups: group 1 (n = 17), who received 0.01 mg/kg nicardipine, group 2 (n = 17), who received 0.02 mg/kg, and group 3 (n = 13), who received 0.03 mg/kg. A spinal needle was inserted into the subarachnoid space to permit continuous measurement of CSFP. Nicardipine produced statistically significant increases in CSFP: from a mean of 7.6 to 11.6 mm Hg in group 1, 7.2 to 12.2 mm Hg in group 2, and 7.4 to 13.8 mm Hg in group 3 (P < 0.001 in each group). CSFP after nicardipine attained its maximum in 1–2 min, then gradually returned to control levels. Changes in CSFP were always associated with statistically significant decreases in arterial blood pressure and cerebral perfusion pressure, whereas the heart rate showed significant increases. Nicardipine may increase CSFP to undesirable levels in patients with intracranial hypertension.

Key Words: BRAIN—cerebrospinal fluid pressure, intracranial pressure • PHARMACOLOGY—calcium channel blockers, nicardipine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.