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Anesth Analg 1986; 65:536-538
© 1986 International Anesthesia Research Society
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Normeperidine Toxicity

Peter J. Armstrong, MB, BS, FFARACS, and Andrew Bersten, MB, BS, FFARACS

Received from the Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, South Australia.

Abstract

Meperidine hydrochloride is the most commonly prescribed opioid analgesic for postoperative pain in our hospital. Biotransformation of meperidine may lead to a potentially toxic metabolite, normeperidine. We describe two cases of apparent normeperidine toxicity and discuss reasons for normeperidine accumulation.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.