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Anesth Analg 1986; 65:781-785
© 1986 International Anesthesia Research Society
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Prolongation of Lidocaine Spinal Anesthesia with Phenylephrine

George T. Vaida, MD, Phillip Moss, MD, Levon M. Capan, MD, and Herman Turndorf, MD

Department of Anesthesiology, New York University Medical Center, 550 First Avenue, New York, New York, and the Department of Anesthesiology, Bellevue Hospital Center, 27th Street and First Avenue, New York, New York.

Abstract

The effect of added phenylephrine on the duration of sensory analgesia during lidocaine spinal anesthesia was determined in 65 ASA class I-III patients randomly divided into three groups. Group 1 (n = 25) received 62.5 mg lidocaine in 7.5% glucose; group 2 (n = 21) received lidocaine with 2 mg phenylephrine; and group 3 (n = 19) received lidocaine with 5 mg phenylephrine. The level of analgesia to pin prick was assessed by an anesthesiologist unaware of the drug combination used. The mean ± SD cephalad level of analgesia did not differ among the groups. In group 1, the times for two- and for four-segment regression of the level of analgesia, and the time for regresson of analgesia to the T-12 dermatome, were 77 ± 19 (1 SD), 99 ± 24, and 109 ± 26 min, respectively. The corresponding values were 98 ± 25, 118 ± 27, and 130 ± 36 min in group 2 and 124 ± 32, 142 ± 31, and 162 ± 35 min in group 3. All the regression times in group 2 were significantly longer than those in group 1 (P < 0.05). All the regression times in group 3 were significantly longer than those in group 2 (P < 0.02). It is concluded that clinically useful prolongation of sensory analgesia may be obtained by addition of phenylephrine to lidocaine during spinal anesthesia.

Key Words: SPINAL ANESTHESIA—lidocaine • VASOPRESSORS—phenylephrine • SENSORY ANALGESIA




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.