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Anesth Analg 1986; 65:840-842
© 1986 International Anesthesia Research Society
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Effects of Cimetidine and Ranitidine on Local Anesthetic Central Nervous System Toxicity in Mice

Kil Chol Kim, MD, PhD, and Mark D. Tasch, MD

Received from the Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana.

Abstract

The effects of cimetidine (5–200 mg/kg), ranitidine (1–100 mg/kg), or saline on local anesthetic central nervous system toxicity was studied when administered 20 min before the administration of lidocaine (30–80 mg/kg) or 2-chloropro-caine (50–250 mg/kg) to female white CD-1 mice. All drugs were administered intraperitoneally. The 50% convulsive dose (CD50) was determined for each drug and dose combination. Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50. A dose of cimetidine (15 mg/kg) that caused a significant decrease in 2-choloroprocaine CD50 (from 180 to 110 mg/kg) caused only an insignificant decrease in lidocaine CD50 (from 59 to 54 mg/kg). If these results can be applied to clinical doses in humans, ranitidine may be a safer premedicant than cimetidine with regard to interactions with local anesthetics.

Key Words: ANESTHETICS, LOCAL—toxicity • GASTROINTESTINAL TRACT, stomach—cimetidine, ranitidine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.