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Anesth Analg 1986; 65:960-962
© 1986 International Anesthesia Research Society
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The Partial Pressure of Isoflurane or Halothane Does Not Affect Their Solubility in Rabbit Blood or Brain or Human Brain

Inhaled Anesthetics Obey Henry's Law

Cara M. Coburn, and Edmond I. Eger, II, MD

Received from the Department of Anesthesia, University of California, San Francisco, San Francisco, California.

Abstract

We tested the possibility that the solubility of halothane or isoflurane in rabbit blood or human or rabbit brain does not obey Henry's Law. We measured the blood/gas and brain/gas partition coefficients for both anesthetics at approximately 1 MAC and at 0.01 MAC at 37°C. The partition coefficients determined at the high vs low partial pressures did not differ. We conclude that the solution of isoflurane and halothane in blood and brain obeys Henry's Law.

Key Words: ANESTHETICS, VOLATILE—halothane, isoflurane • SOLUBILITY—halothane, isoflurane • PHYSICS—Henry's law




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.