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Partition Coefficients of I-653 in Human Blood, Saline, and Olive Oil

Received from the Department of Anesthesia, University of California, San Francisco, California.

Abstract

The purpose of this study was to determine partition coefficients for a new, inhaled anesthetic, I-653. Blood samples were taken from 11 patients scheduled for elective surgery who were ASA physical status I-III and ranged in age from 25 to 76 yr. At 37°C, we found a blood/gas partition coefficient of 0.424 ± 0.024 (mean ± sd); a saline/gas partition coefficient of 0.225 ± 0.002; and an oil/gas partition coefficient of 18.7 ± 1.1. These values indicate that I-653 will have a minimum alveolar concentration (MAC) required for anesthesia that is four to five times that of isoflurane and that I-653 will produce a rapid induction of and recovery from anesthesia.

Key Words: ANESTHETICS, VOLATILE—I-653 • SOLUBILITY—I-653 partition coefficients

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