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MAC of I-653 in Rats, Including a Test of the Effect of Body Temperature and Anesthetic Duration

Received from the Department of Anesthesia, University of California, San Francisco, California.

Abstract

The anesthetic potency of a new fluorinated volatile anesthetic, I-653, was tested preliminary to testing its toxic and metabolic characteristics in rats. The minimum alveolar concentration (MAC) of 1–653 at 37.9 ± 0.2°C (mean ± sd) in eight rats was 5.72 ± 0.40%. In five rats, we reduced the rectal temperature to 28°C in two steps of 5°C. MAC decreased by 0.238 ± 0.036% I-653 per degree centigrade decrease in temperature. That is, MAC decreased 42% as temperature decreased 10°C. We restored the temperature to38°C and redetermined MAC. This value (5.66 ± 0.75%) did not differ from the average MAC obtained before hypothermia (5.84 ± 0.36%).

Key Words: ANESTHETICS, VOLATILE—I-653 • POTENCY, ANESTHETIC-I-653

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999