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Anesth Analg 1987; 66:999-1003
© 1987 International Anesthesia Research Society
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Analgesic and Cardiorespiratory Effects of Epidural Sufentanil and Morphine in Humans

Dirk Van der Auwera, MD, Christian Verborgh, MD, and Frederic Camu, MD

Received from the Department of Anesthesiology, Flemish Free University of Brussels Medical School, Laarbeeklaan 101, B-1090 Brussels, Belgium.

Abstract

Thirty patients undergoing abdominal surgery were randomly assigned postoperatively into two groups for a double-blind evaluation of the analgesic potency and cardiorespiratory effects of either 50 µg sufentanil or 5 mg morphine injected epidurally. After sufentanil injection, good post-operative analgesia was obtained, with a linear analog score (LAS) of less than 5 starting 5 min after injection and lasting for more than 6 hr. Linear analog scores obtained during coughing (LASC) and during movement (LASM) were less than 5 after 10 min and lasted for more than 4 hr. Respiratory rate decreased significantly for 2 hr after sufentanil injection. After morphine, pain relief started after 20 min and lasted for more than 12 hr. Respiratory rate decreased after 30 min. Sedation was greater after sufentanil than after morphine. PaCO2, which increased significantly 1 hr after sufentanil, did not change after morphine. Peak expiratory flow significantly improved for 2 hr after both sufentanil and morphine, whereas forced vital capacity improved for 4 hr after sufentanil and 8 hr after morphine administration. Forced expiratory volume did not change with either drug. It is concluded that 5 mg morphine injected epidurally provides longer lasting analgesia than does 50 µg sufentanil, but that in the first hours analgesia is better after sufentanil. Injection of either drug was accompanied by remarkable cardiovascular stability.

Key Words: PAIN—POSTOPERATIVE • ANALGESICS—morphine, sufentanil • ANESTHETIC TECHNIQUES—EPIDURAL




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.