| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
Received from the Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Abstract
The effects of fentanyl and sufentanil on peripheral nerves were evaluated in isolated sheathed and desheathed rabbit vagus nerves. The action potential amplitudes of A and C fibers were recorded before and after a 30-min exposure to 50 and 100 µg/ml of fentanyl and sufentanil. A reversible decrease in the action potential amplitude of A fibers in desheathed nerves was observed after exposure to 100 µg/ml of each drug. The action potential amplitude of C fibers was also decreased but not to the same degree as was the A fiber action potential. Pretreatment with naloxone failed to block the reduction in action potential amplitude produced by the two opiates. No evidence of irreversible conduction blockade indicative of local neural toxicity was seen in these studies. The results suggest that high concentrations of fentanyl and sufentanil may exert a weak local anesthetic-type action on peripheral nerves.
Key Words: ANALGESICS—fentanyl, sufentanil • NERVES—fentanyl, sufentanil
This article has been cited by other articles:
|
|
 |
|
  C.-H. Cherng, C.-P. Yang, and C.-S. Wong Epidural Fentanyl Speeds the Onset of Sensory and Motor Blocks During Epidural Ropivacaine Anesthesia Anesth. Analg., December 1, 2005; 101(6): 1834 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Akerman, S. Saxena, R. Wilson, M. Columb, and G. Lyons Effect of intrathecal diamorphine on block height during spinal anaesthesia for Caesarean section with bupivacaine Br. J. Anaesth., June 1, 2005; 94(6): 843 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Eichenberger, C. Giani, S. Petersen-Felix, T. Graven-Nielsen, L. Arendt-Nielsen, and M. Curatolo Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain Br. J. Anaesth., April 1, 2003; 90(4): 467 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Altunkaya, Y. Ozer, E. Kargi, and O. Babuccu Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures Br. J. Anaesth., March 1, 2003; 90(3): 320 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W.B. Hartmannsgruber, P. G. Atanassoff, A. Budde, S. J. Brull, Z. N. Kain, and D. G. Silverman Intradermal sufentanil does not improve lidocaine-induced local anesthesia: [L'administration intradermique de sufentanil n'ameliore pas l'anesthesie locale induite par la lidocaine] Can J Anesth, February 1, 2003; 50(2): 153 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Goodarzi and R. R. Narasimhan The Effect of Large-Dose Intrathecal Opioids on the Autonomic Nervous System Anesth. Analg., August 1, 2001; 93(2): 456 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Tsai, P.-J. Chang, and I-M. Jou Direct Tramadol Application on Sciatic Nerve Inhibits Spinal Somatosensory Evoked Potentials in Rats Anesth. Analg., June 1, 2001; 92(6): 1547 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishikawa, N. Kanaya, M. Nakayama, M. Igarashi, K. Tsunoda, and A. Namiki Fentanyl Improves Analgesia but Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral Mechanism Anesth. Analg., August 1, 2000; 91(2): 384 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hansen and S. Hansen The Effects of Three Graded Doses of Meperidine for Spinal Anesthesia in African Men Anesth. Analg., April 1, 1999; 88(4): 827 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. H. Sia, J. L. Chong, and J. W. Chiu Combination of Intrathecal Sufentanil 10 {micro}g Plus Bupivacaine 2.5 mg for Labor Analgesia: Is Half the Dose Enough? Anesth. Analg., February 1, 1999; 88(2): 362 - 362. [Abstract] [Full Text] [PDF]
|
|
|
