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Anesth Analg 1987; 66:1282-1286
© 1987 International Anesthesia Research Society
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The Effect of Meperidine on the Guinea Pig Extrahepatic Biliary Tract

Meir Goldberg, MD, Elik Vatashsky, MD, Yuval Haskel, MD, Dan Seror, MD, Shemuel Nissan, MD, and Menachem Hanani, PhD

From the Department of Surgery, Laboratory of Experimental Surgery and the Department of Anesthesiology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.

Abstract

The effect of meperidine on the mechanical activity of isolated guinea pig common bile duct (CBD) and gallbladder was studied in vitro. The effect was found to consist of inhibitory and excitatory phases. The inhibitory phase, characterized by a decrease in the response of the CBD and gallbladder to carbachol and electrical stimulation, was seen with concentrations of 10–6 M or higher. The excitatory phase, seen at high concentrations of meperidine (5 x 10 5-10–4 M), involved an increase in spontaneous contractions of CBD and in the tone of the gallbladder. Neither effect of meperidine was affected by 0.5 x 10–5 M naloxone. These data indicate that meperidine acts on the biliary tract by a mechanism different from that associated with the effect of morphine.

Key Words: LIVER—bile ducts • ANALGESICS—meperidine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.