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Anesth Analg 1987; 66:607-614
© 1987 International Anesthesia Research Society
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ß-Blockade Reverses Regional Dysfunction in Ischemic Myocardium

Bruce J. Leone, MD, Jean-Jacques Lehot, MD, C. Mark Francis, DPhil, Geoffrey R. Cutfield, MD, ChB, DPhil, and Pierre Foëx, MD, DPhil

Received from the Nuffield Department of Anaesthetics, Oxford University, Oxford, England; the Departement d'Anesthesie-Reanimation Hopital Cardiovasculaire et Pneumologique L, Pradel, Lyon, France; and the Department of Anesthesiology, University of Texas Southwestern Medical School, Dallas, Texas. Address correspondence to Dr. Foex, Nuffield Department of Anaesthetics, The Radcliffe Infirmary, Woodstock Road, Oxford, U.K. OX2 6HE.

Abstract

To determine the protective effect of oxprenolol-induced ß-blockade on the compromised myocardium (critical constriction of the left anterior descending coronary artery) against the adverse effect of high concentrations of halothane, halo-thane dose-response curves were obtained in six dogs in each of three phases: preconstriction (control), critical constriction, and critical constriction with the addition of 0.3 mg/kg intravenous oxprenolol. The extent of depression of ventricular function was essentially the same in the three phases. However, at high halothane concentrations (2.0% inspired), the depression of systolic shortening in the compromised segment was significantly minimized after oxprenolol so that shortening was 10.2% ± 1.8 instead of 6.5% ± 1.4 (P<0.05); moreover the large increase in postsystolic shortening observed during critical constriction was abolished after oxprenolol. This suggests a protective effect of oxprenolol on regional myocardial function in the presence of critical constriction, possibly by an effect on myocardial metabolism or endocardial blood flow.

Key Words: HEART, MYOCARDIAL FUNCTION—ß-blockade.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.